Adult Onset Still's Disease and Autoinflammation
نویسندگان
چکیده
1Rheumatology Division, Lincoln Medical & Mental Health Center, 234 E. 149th st, New York, NY 10451, USA 2Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA 3Division of Pediatric Rheumatology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 1 Robert Wood Johnson Place, New Brunswick, NJ 08901, USA 4Department of Physiology, School of Medicine, University of Athens, M. Asias 75, 11527 Athens, Greece 5 Immunity & Inflammation Department, Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill River Road Tarrytown, NY 10591, USA 6Pierre et Marie Curie University (Paris 6), Service de Rhumatologie, Groupe Hospitalier Pitié-Salpêtrière, 83 Boulevard de l’Hôpital, 75013 Paris, France
منابع مشابه
[Adult-onset Still's disease--a diagnostic challenge].
Adult-onset Still's disease is a rare systemic inflammatory illness. The condition is difficult to diagnose because the illness can resemble sepsis and other well known conditions. This case report concerns a 67 year-old woman with adult-onset Still's disease in two rare manifestations: acute respiratory distress syndrome and neurological manifestation in the form of Gullain Barré syndrome.
متن کاملComparison of long term evolution of adult onset and juvenile onset Still's disease, both followed up for more than 10 years.
Still's disease is a clinical entity of unknown origin, which can appear before 15 years of age (juvenile onset Still's disease) or later (adult onset Still's disease). There are few reported data about the long term prognosis of Still's disease and no study compares the long term evolution of adult onset and juvenile onset Still's disease. Eighteen patients fulfilling the American Rheumatism A...
متن کاملEffect of Ultrasound Therapy on Adult-Onset Still\'s Disease: A Case study
Adult-Onset Still's Disease (AOSD) is a rare systemic inflammatory disease of unknown etiology and pathogenesis. AOSD presents in 5% to 10% of patients as Fever of Unknown Origin (FUO) accompanied by systemic manifestations. We reported a compelling case of a 39-year-old African male presenting one-month FUO along with skin rash, sore throat, and arthralgia. After an extensive workup, potential...
متن کاملGerminal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker
BACKGROUND Germinal center kinase-like kinase (GLK, also termed MAP4K3), a member of the MAP4K family, may regulate gene transcription, apoptosis and immune inflammation in response to extracellular signals. The enhanced expression of GLK has been shown to correspond with disease severity in patients with systemic lupus erythematosus. We investigated the role of GLK in the pathogenesis of adult...
متن کاملSevere restrictive pulmonary defect in a patient with adult-onset Still's disease.
Adult-onset Still's disease is characterized by seronegative arthritis, fever, and an evanescent skin rash. Earlier reports have described pneumonitis and pleuritis as manifestations of this disease. We report a patient with adult-onset Still's disease with severe restrictive ventilatory impairment and evidence of respiratory muscle weakness who responded to corticosteroid and aspirin therapy.
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ورودعنوان ژورنال:
دوره 2012 شماره
صفحات -
تاریخ انتشار 2012